Myocardial Ischemia-Reperfusion Injury: Major Pathobiology and Putative Cardioprotection
نویسندگان
چکیده
منابع مشابه
Spotlight on cardioprotection against ischemia-reperfusion injury.
Worldwide, coronary heart disease (CHD) causes approximately one-third of all deaths in men and one-quarter of all deaths in women and represents a significant threat to public health. The global burden of CHD in terms of disability-adjusted life years (DALY) or " healthy years of life lost " is projected to increase from around 47 million DALY globally in 1990 to 82 million in 2020 [1]. Myocar...
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Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4). Treatment and prevention of perioperative morbidity associated with myocardial I-R will ultimately require a multifocal approach. Combini...
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Cardiovascular diseases are still the main cause of mortality around the world. Therefore, it is essential to develop practical means to reduce their burden. A wealth of evidence supports the role of physical exercise in attenuating many of the risk factors of cardiovascular diseases. Moreover, endurance training warrants protection against myocardial infarction. Exercise, even if performed ...
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The aim of the present study was to investigate the involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions mediated by bradykinin via the combined inhibition of angiotensin converting enzyme and aminopeptidase P in an in vivo rat model of acute ischemia (30 min) and reperfusion (4 h). Myocardial infarction was produced by occlusion of the left anterior descending...
متن کاملPast and present course of cardioprotection against ischemia-reperfusion injury.
Despite tremendous advances in cardiovascular research and clinical therapy, ischemic heart disease remains the leading cause of serious morbidity and mortality in western society and is growing in developing countries. For the past 5 decades, many scientists have studied the pathophysiology of myocardial ischemia-reperfusion (I/R) injury leading to infarction. With the exception of reperfusion...
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ژورنال
عنوان ژورنال: THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA
سال: 2010
ISSN: 0285-4945,1349-9149
DOI: 10.2199/jjsca.30.40